Ustekinumab (Stelara)

Description

Ustekinumab (Stelara) is a human monoclonal antibody that binds to and interferes with the proinflammatory cytokines, interleukin (IL)-12 and IL-23.

Crohn disease:
It is used in the treatment of moderately to severely active Crohn disease in adults who have failed or were intolerant to immunomodulatory or corticosteroid therapy, but never failed tumor necrosis factor (TNF) inhibitor therapy or who were intolerant or have failed treatment with one or more TNF blockers.

Plaque psoriasis:
It is used in the treatment of moderate to severe plaque psoriasis in patients ?12 years of age who are candidates for phototherapy or systemic therapy

Psoriatic arthritis:
It is used in the treatment of active psoriatic arthritis (as monotherapy or in combination with methotrexate) in adults